Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding
نویسندگان
چکیده
منابع مشابه
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope.
HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat 1 (HR1) domain is the molecular target of the fusion-inhibitor drug enfuvirtide (T20). The HR1 sequence is highly conserved and therefore considered an attractive target for vaccine development, but it is unknown whether antibodies can ac...
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ژورنال
عنوان ژورنال: Emerging Microbes & Infections
سال: 2015
ISSN: 2222-1751
DOI: 10.1038/emi.2015.44